Re quincunxes: I think that a helpful way to understand them is to consider the natural quincunx Signs. I won't go through them all here, but just for example...Gemini is quincunx Scorpio. Gemini (mutable air) 'skims'; Scorpio (fixed water) 'digs deep'. Gemini is also quincunx Capricorn (mutable air and cardinal earth). They're 'out of synch' so they have to keep 'adjusting' to the energies of each other. And of course, the same with all the other Sign quincunxes.
So, taking that a bit further, any planets that are inconjunct with each other require a constant need for adjustment between their energies. The planet that is most strongly placed, as in if, for example, it is in the Sign it 'rules' (and according to how much it is 'helped' by strong positive aspects to other planets), will tend to be dominant within the quincunx, This suggests that this constant need to adjust between the two (or more) energies, can be unsettling, stressful, and tiring, to the point that it can affect one's health.
These are also, of course, affected by transits. A conjunction by a planet to one of them (especially from an 'outer' planet) is going to emphasise that 'energy' very strongly, so, the other planet in quincunx, is constantly struggling to express itself. (A few writers have even suggested that it's almost like an opposition because of the constant struggle).
This is of course, purely the result of my own investigations into this matter. Always open and ready to listen to the ideas of others, not least of all because everything in our world is changing so fast now, especially in astrological realms.
"There are more things...likely to frighten us than there are to crush us; we suffer more often in imagination than in reality." Seneca